A series of special topics on the introduction of the technology of nodule Zinni
【Preface】Zhengzhou Zhongpu Medical Equipment Co., Ltd. is a high-tech enterprise focusing on the research and development, production and sales of tuberculosis smear, acid-fast dyeing, intelligent scanning products. The company has a number of national invention patents for tuberculosis smears diagnostic technology, and is one of the enterprises with the most complete product categories and the most mature technology of tuberculosis smears, acid-fast dyeing, intelligent scanning. The company launched the fully automatic tuberculosis smear intelligent scanning scanner, which is a new generation of tuberculosis smear intelligent scanning and diagnostic equipment independently created by Zhengzhou Zhongpu after 4 years. It has the obvious characteristics of extremely fast scanning speed, high accuracy, and flux upgrade in the original machine.
Depth analysis
Select 100 times objective lens to scan, is really very important, or will directly affect the positive rate of reading film!
Now we know that Ziezini's scanners, different manufacturers use different objective scans: 40 times, 60 times, 100 times useful, the reason why, or different researchers have different understanding of TB scanning.
Mycobacterium tuberculosis is a rod-shaped bacterium that is 3-8 microns long and 0.3-0.6 microns in diameter. The microscopic diagnostic standard of tuberculosis smear staining is observation and diagnosis under 100 times oil microscope. The reason why the diagnostic criteria are observed under 100-fold oil lens is mainly due to the fact that the tuberculosis bacillus itself is too small. Under Ziezini's staining, 100-fold oil lens can better distinguish the unique knotlike structure of tuberculosis bacillus, which is different from the diagnostic interference caused by other impurities (non-decolorization will bring red impurity interference).
Therefore, the number of times of objective lens scanning will directly determine the observation magnification and clarity of the visual field target, the use of different magnification of objective lens scanning, or will directly determine the scanner identification accuracy of mycobacterium tuberculosis.
Whether a 40x, 60x or 100x objective is used to scan, the proportion of the object directly magnified is fixed (this is not disputed), and the proportion of the image magnified to the scanner camera is fixed (this is not disputed at all).
Therefore, if a camera with the same pixel is used to shoot, the size of the image presented is fixed. Of course, it is theoretically possible to compensate for the low magnification of the objective lens by increasing the pixel size of the camera. If you use a 100x objective lens for a 2.3 megapixel camera, then a 40x objective lens should be used for a 5.75 megapixel camera and a 60x objective lens should be used for a 3.84 megapixel camera. As a result, the higher the pixels, the more data you get, the longer it takes to transmit, the longer it takes to scan, and the cost doubles.
Therefore, the objective lens with different magnification will directly determine the identification effect of mycobacterium tuberculosis, and then affect the positive rate of reading the film.
Note:
Tuberculosis bacilli also show different forms at different stages of treatment. In the early stage, most of them are long rod-shaped, which is easy to identify, while in the later stage of treatment, they often become short and thick. If the imaging is too small, it is difficult to identify them.
The instrument scan is a blind scan, requiring the identification and filtering out of the TB bacilli in the sample. The higher the magnification, the larger the image and the higher the likelihood of identification.
Zhengzhou Zhongpu R & D team through repeated testing of 40 times, 60 times and 100 times objective lens scanning, research found that: if for more than 1+ positive smear, the scanning results of the above different objectives are little different, but if for 1+ smear scanning, we found that the recognition rate of scanning is just proportional to the multiple of the objective lens. That is, the higher the multiple, the higher the recognition rate; The lower the multiple, the greater the chance of a missed test.
Here's the point:
If there is only a good response to smears above 1+, the existence of the TB scanner is meaningless. Because, more than 1+ smear, manual scan diagnosis is quite fast, there is no need to scanner.
The biggest difficulty of TB scanning technology is to scan for smears less than 1+. In such smears, the TB bacteria are rarely distributed, and if the imaging is too small, it is easy to miss the diagnosis.
The research and development team of Zhengzhou Zhong Pu deeply analyzed the different characteristics of tuberculosis before and after treatment -- the fact that tuberculosis bacilli present different forms in different treatment periods. Combined with the industry standard requirements for the diagnosis of tuberculosis smear, we still insist on using 100 times objective for Zini staining scanning, because it can maximize the positive rate of tuberculosis smear reading.
Technical comparison：
Zhengzhou Zhongpu tuberculosis smear intelligent scanner:The 100-fold objective scan is in line with the diagnostic criteria of tuberculosis Zini's, and can provide a higher positive rate of scanning film.A 40x objective scan can also be provided, but scanning during Ziezini's staining is not recommended during training.
Conventional scanners: Scans that use 40X or 60x scans and are not performed as required for TB diagnosis may have more missed detection.
We offer a 100-fold oil lens scan that meets the diagnostic requirements of Ziezini's staining for tuberculosis microscopy -- providing more possibilities for increasing the positive rate of reading film.
We provide 100-fold objective scan -- it is in line with the requirements of tuberculosis diagnosis and help to improve the positive rate of reading film thinking!
Zhengzhou Zhongpu automatic tuberculosis Zini staining scanner, which meets the requirements of diagnostic standards and helps to improve the positive rate of reading film.
Zhengzhou Zhongpu tuberculosis smear intelligent scanning platform more applications: automatic tuberculosis smear intelligent scanning platform, in addition to providing tuberculosis smear intelligent scanning diagnosis, can also be expanded to: Intelligent diagnosis of blood smear Plasmodium scanning, liquid based cell intelligent diagnosis, thyroid puncture cell intelligent diagnosis, bacterial smear Gram staining intelligent diagnosis, human body fluid parasite (egg) intelligent diagnosis, clinical blood smear white blood cell analysis diagnosis, clinical bone marrow cell smear intelligent diagnosis and other medical microbial morphological intelligent diagnosis techniques.
——Zhengzhou Zhongpu focus on sputum screening and detection of tuberculosis——
Zhengzhou Zhongpu focus on tuberculosis sputum screening detection, R & D team unremitting efforts, again and again to refresh the record, constantly beyond, this technological innovation, greatly shorten the time of tuberculosis detection, improve the efficiency of medical testing units of tuberculosis detection, to ensure the accuracy of the test results. With intangible value to create countless value, Zhengzhou Zhongpu escort for human health!
